代表文章 Representative Publications(#共同一作，*通讯作者)
1. Nie Y#, Qiu Z#, Chen Z, Song X, Ma Y, Cyster JG, Zheng S* (2023). Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling. Nature Communications 14 (1).
2. Jiang W#, Wang W#, Kong Y, Zheng S* (2023). Structural basis for the ubiquitination of G protein βγ subunits by KCTD5/Cullin3 E3 ligase. Science Advances 9 (28).
3. Yang J, Chen P, Cao Y, Liu S, Wang W, Li L, Li J, Jiang Z, Ma Y, Chen S, Zheng S, Qi X*, Jiang H*(2023). Chemical inhibition of mitochondrial fission via targeting the DRP1-receptor interaction. Cell Chemical Biology 30 (3).
4. Wang Q#, Meng F#, Xie Y, Wang W, Meng Y, Li L, Liu T, Qi J, Ni X, Zheng S, Huang J*, Huang N*(2023). In Silico Discovery of Small Molecule Modulators Targeting the Achilles’ Heel of SARS-CoV-2 Spike Protein. ACS central science 9 (2).
5. Chen S, Teng X, Zheng S* (2023). Molecular basis for the selective G protein signaling of somatostatin receptors. Nature Chemical Biology 19 (2): 133-140.
6. Li Y#, Liu J#, Chen W#, Wang W, Yang F, Liu X, Sheng Y, Du K, He M, Lyu X, Li H, Zhao L, Wei Z, Wang F, Zheng S, Sui J*(2023). A pH-dependent anti-CD47 antibody that selectively targets solid tumors and improves therapeutic efficacy and safety. Journal of Hematology & Oncology 16 (1).
7. Jiang W, Zheng S* (2022). Structural insights into the galanin receptors signaling. Proc. Natl. Acad. Sci. U.S.A 119 (21).
8. Teng X#, Chen S#, Wang Q, Chen Z, Wang X, Huang N, Zheng S* (2022). Structural insights into G protein activation by D1 dopamine receptor. Science Advances 8 (23)
9. Teng X, Chen S, Nie Y, Zheng S* (2022). Ligand recognition and biased agonism of the D1 dopamine receptor. Nature communications 13 (1), 1-11.
10. Ma J#, Su D#, Sun Y, Huang X, Liang Y, Fang L, Ma Y, Li W, Liang P*, Zheng S* (2021). Cryo-electron microscopy structure of S-trimer, a subunit vaccine candidate for COVID-19. Journal of Virology 95 (11).
11. Pascolutti R, Erlandson SC, Burri DJ, Zheng S, Kruse AC* (2020). Mapping and engineering the interaction between adiponectin and T-cadherin. J Bio Chem 295 (9), 2749-2759
12. Sjodt M, Rohs PD, Gilman MS, Erlandson SC, Zheng S, Green AG, Brock KP, Taguchi A, Kahne D, Walker S, Marks D, Rudner DZ, Bernhardt TG, Kruse AC* (2020). Structural coordination of polymerization and crosslinking by a SEDS-bPBP peptidoglycan synthase complex. Nature Microbiology 5 (6), 813-820
13. Liu H, Zheng S, Hou X, Liu X, Du K, Lv X, Li Y, Yang F, Li W, Sui J* (2020). Novel Abs targeting the N-terminus of fibroblast growth factor 19 inhibit hepatocellular carcinoma growth without bile-acid-related side-effects. Cancer science 111 (5), 1750-1760
14. Zheng S, Abreu N, Levitz J, Kruse AC* (2019). Structural basis for KCTD-mediated rapid desensitization of GABAB signaling. Nature 567: (127-131).
15. Zheng S, Sham LT, Rubino FA, Brock KP, Robins WP, Mekalanos JJ, Marks DS, Bernhardt TG, Kruse AC*. (2018) Structural and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli. Proc. Natl. Acad. Sci. U.S.A 115 (26): 6709-6714
16. Sham LT, Zheng S, Yakhnina AA, Kruse AC, Berhardt TG*. (2018) Loss of specificity variants of WzxC suggest that substrate recognition is coupled with transporter opening in MOP-family flippase. Mol Microbiol 109 (5): 633-641
17. Huang P#, Zheng S#, Wierbowski BM, Kim Y, Nedelcu D, Aravena L, Liu J, Kruse AC., Salic A*. (2018) The structural basis of smoothened activation in Hedgehog signaling. Cell 174: 1-13
18. MaMahon C, Baier AS, Pascolutti R, Wegrecki M, Zheng S, Ong JX, Erlandson SC, Hilger D, Rasmussen SGF, Ring AM, Manglik A*, Kruse AC*. (2018) Yeast surface display platform for rapid discovery of conformationally selective nanobodies. Nature Structural & Molecular Biology 25: 289-296
19. Zhou D#, Zhu X#, Zheng S, Tan D, Dong MQ, Ye K*. (2018) Cryo-EM structure of an early precursor of large ribosomal subunit reveals a half-assembled intermediate. Protein Cell 10 (2): 120-130
20. Sun Q#, Zhu X#, Qi J#, An W#, Lan P, Tan D, Chen R, Wang B, Zheng S, Zhang C, Chen X, Zhang W, Chen J, Dong M, Ye K*. (2017) Molecular architecture of the 90S small subunit pre-ribosome. eLife 6: e2208
21. Li D, He W, Liu X, Zheng S, Qi Y, Li H, Mao F, Liu J, Sun Y, Pan L, Du K, Ye K, Li W*, Sui J*. (2017) A potent human neutralizing antibody Fc-dependently reduces established HBV infections. eLife 6: e26738
22. Schmidt HR#, Zheng S#, Gurpinar E, Koehl A, Manglik A., Kruse AC*. (2016) Crystal structure of human sigma1 receptor. Nature 532: 527-530
23. Shen M#, Zhang N#, Zheng S#, Zhang W, Zhang H, Lu Z, Su Q, Sun Y, Ye K, Li X*. (2016) Calmodulin in complex with the first IQ motif of myosin-5a functions as an intact calcium sensor. Proc. Natl. Acad. Sci. U.S.A 113 (40)
24. Zheng S#, Lan P#, Liu X, Ye K*. (2014) Interaction between Ribosome Assembly Factors Krr1 and Faf1 Is Essential for Formation of Small Ribosomal Subunit in Yeast. J Bio Chem 289: 22692-703
25. Zheng S, Villa R, Wang J, Feng Y, Wang J, Becker PB, and Ye K*. (2014) Structural basis of X chromosome DNA recognition by MSL2 CXC domain during dosage compensation in Drosophila. Genes & Development 28: 2652-2662
26. Zheng S#, Wang J#, Feng Y#*, Wang J, Ye K*. (2012) Solution structure of MSL2 CXC domain reveals an unusual Zn3Cys9 cluster and similarity to pre-SET domains of histone lysine methyltransferases. PloS One 7: e45437
Invited reviews and comments
1. Zheng S, Kruse AC*. (2019) Ion Channels: Solving a specificity mystery. eLife
2. Alon A#, Schmidt H#, Zheng S#, Kruse AC*. (2017) Structure perspectives on Sigma-1 receptor function. Adv Exp Med Biol. 964:5-13
