李超博士

清华大学生物医学交叉研究院助理教授，北京生命科学研究所研究员

Chao Li, Ph.D. Assistant Professor, TIMBR, Assistant Investigator, NIBS, Beijing, China

实验室主页：http://www.lichaolab.com

教育经历 Education

2013北京生命科学研究所与天津大学联合培养有机合成化学博士

Ph.D. in Organic Synthesis, National Institute of Biological Science (NIBS), Beijing & Tianjin University, Tianjin, China.

2008青岛科技大学制药工程学士

B.S., Pharmaceutical Engineering, Qingdao University of Science and Technology, Qingdao, China

工作经历 Professional Experience

2017-Present

清华大学生物医学交叉研究院助理教授，北京生命科学研究所研究员

Assistant Professor, TIMBR, Assistant Investigator, National Institute of Biological Sciences, Beijing

2014-2017年

美国斯克里普斯研究所博士后

研究概述 Research Description

化学小分子在认知，干扰与调节生物过程中发挥着重要的作用。我们课题组致力于在开拓合成化学空间的基础上，利用获得的活性小分子发现与人类重大疾病相关的药物作用靶标和先导化合物。同时设计合成具有重要生物学利用价值的化学工具分子。具体的研究内容包括：

（1）利用新型催化体系研究新颖的化学键构建方法，为化学分子的合成提供更理想的策略。

（2）选择与重大疾病相关的天然产物进行合成及活性优化，进而推动创新药物的研究;

（3）探索活性天然小分子的生物学作用机制和其作用靶标;

（4）设计合成能够选择性标记，追踪生物大分子或识别其相互作用的化学工具分子。

我们实验室诚挚地欢迎想利用化学手段解决生物学问题的科学家加入。

Small molecules are of paramount importance in the recognition, modulation and regulation of biological processes. The research of our group explores the interface between chemical synthesis and biology, by pursuing the efficient synthesis of structurally novel and therapeutically potent small molecules prior to probing their mechanism of action and functional targets. Our specific research interests include the following:

• Development of new catalytic reactions for the efficient construction of chemical bonds, thereby providing practical synthetic methods for “ideal synthesis”.

• Total synthesis of structurally complex and bioactive natural products.

• Exploring the mechanism of action and the functional targets of bioactive small molecules.

• Development of novel molecular probes to study the interactions between biological macromolecules.

代表文章 Representative Publications

19.Li, Z.; Sun, W.; Wang, X.; Li, L; Zhang, Y.; Li, C.* “Electrochemically Enabled, Nickel-Catalyzed Dehydroxylative Cross-Coupling of Alcohols with Aryl Halides” J. Am. Chem. Soc. 2021, 143, 3536-3543.

18. Xu, G.#; Wu, J.#; Li, L.; Lu, Y.; Li, C.* “Total Synthesis of (-)-Daphnezomines A and B” J. Am. Chem. Soc. 2020, 142, 15240-15245.

17. Zhuo, J.#; Zhang, Y.#; Li, Z.; Li, C.* “Nickel-Catalyzed Direct Acylation of Aryl and Alkyl Bromides with Acylimidazoles”. ACS Catal. 2020, 10, 3895-3903.

16.Zhang, J.#; Li, Z.#; Zhuo, J.; Cui, Y.; Han, T.; Li, C.* “Tandem Decarboxylative Cyclization/Alkenylation Strategy for Total Syntheses of (+)-Longirabdiol, (-)-Longirabdolactone, and (-)-Effusin” J. Am. Chem. Soc. 2019, 141, 8372-8380.

15. Li, C.#; Kawamata, Y.#; Nakamura, H.; Vantourout, J. C.; Liu, Z.; Hou, Q.; Bao, D.; Star, J. T.; Chen, J.; Yan, M.; Baran, P. S.* “Electrochemically Enabled, Ni-Catalyzed Amination” Angew. Chem. Int. Ed. 2017, in press

14.Li, C.^#; Wang, J.^#; Barton, L. M.; Yu, S.; Tian, M.; Peters, D. S.; Kumar, M.; Yu, A. W.; Johnson, K. A.; Chatterjee, A. K.; Yan, M.; Baran, P. S.* “Decarboxylative Borylation”Science,2017,356, 1045.

13.Qin, T.^#; Cornella, J.^#;Li, C.^#; Malins, L. R.; Edwards, J. T.; Kawamura, S.; Maxwell, B. D.; Eastgate, M. D.; Baran, P. S.* “A General Alkyl-Alkyl Cross-Coupling Enabled by Redox-Active Esters and Alkylzinc Reagents”Science2016,352,801-805

12.Li, C.; Jones, A. X.; Lei, X.* “Synthesis and Mode of Action of Oligomeric Sesquiterpene Lactones”Nat. Prod. Rep.2016,33,602-611.

11.Li, D.^#;Li, C.^#; Li, L.; Chen, S.; Wang, L.; Li, Q.; Wang, X.;Lei, X.*; Shen, Z.* “Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis”Cell Chemical Biology2016,23, 257-266.

10.Hong, B.^#;Li, C.^#; Wang, Z.; Chen, J.; Li, H.*; Lei, X.* “Enantioselective Total Synthesis of (−)-Incarviatone A”J. Am. Chem. Soc.2015,137, 11946-11949.

9.Dao, H. T.;Li, C.; Michaudel, Q.; Maxwell, B. D.; Baran, P. S.* “Hydromethylation of Unactivated Olefins”J. Am. Chem. Soc.2015,137, 8046-8049.

8.Dong, T.^#;Li, C.^#; Wang, X.; Dian, L.; Zhang, X.; Li, L.; Chen, S.; Cao, R.; Li, L.; Huang, N.; He, S.;* Lei, X.* “Ainsliadimer A Selectively Inhibits IKKα/β by Covalently Binding a Conserved Cysteine”Nature Commun.2015, 6, 6522.

7.Li, C.^#; Dong, T.^#; Li, Q.; Lei, X.* “Probing the Anticancer Mechanism of (−)-Ainsliatrimer A through Diverted Total Synthesis and Bioorthogonal Ligation”Angew. Chem. Int. Ed.2014,53, 12111-12115.

6.Li, C.; Lei, X.*“Strategies toward the Biomimetic Syntheses of Oligomeric Sesquiterpenoids”J. Org. Chem.2014,79, 3289-3295.

5.Li, C.; Dong, T.; Dian, L.; Zhang, W.; and Lei, X.* “Biomimetic Syntheses and Structural Elucidation of the Apoptosis-Inducing Sesquiterpenoid Trimers: (-)-Ainsliatrimers A and B”Chem. Sci.2013,4,1163-1167.

4.Li, C.; Li, X.; Wang, X.; Lei, X.* “Diversity-oriented Synthesis of Bicyclic Ring Systems via a Conjugate Addition/aldol/RCM Process”Sci. China. Chem.2013,56, 337-341.

3.Li, C.; Dian, L.; Zhang, W.; Lei, X.* “Biomimetic Syntheses of (-)-Gochnatiolides A-C and (-)-Ainsliadimer B”J. Am. Chem. Soc.2012,134, 12414-12417.

2.Li, C.; Tu, S.; Wen, S.; Li, S.; Chang, J.; Shao, F, Lei, X.* “Total Synthesis of the G2/M DNA Damage Checkpoint Inhibitor Psilostachyin C”J. Org. Chem.2011,76, 3566-3570.

1.Li, C.; Yu, X.; Lei, X.* “A Biomimetic Total Synthesis of (+)-Ainsliadimer A”Org. Lett.2010,12, 4284-4287.

专利 Patents

1.Lei, X.; He, S.;Li, C.; Dong, T. “Sesquiterpenoids” PCT/CN2014/076123. US Pat No. 9670226.

2.Baran, P. S.;Li, C.; Wang, J.; Chatterjee, A. K.; Kumar, M.; Yu, S.; Johnson, K. A.; “Decarboxylative Borylation” under review.