韩霆博士

清华大学生物医学交叉研究院助理教授，北京生命科学研究所研究员

Ting Han, Ph.D. Assistant Professor, TIMBR, Assistant Investigator, NIBS, Beijing, China

教育经历 Education

2006年 清华大学 生物学学士学位

B.S. Biology, Tsinghua University, Beijing, China

2013年 美国密西根大学细胞和发育生物学博士

Ph.D. Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA

工作经历 Professional Experience

2017- 清华大学生物医学交叉研究院助理教授，北京生命科学研究所研究员

Assistant Professor, TIMBR, Assistant Investigator, National Institute of Biological Sciences, Beijing, China

2013-2017美国德克萨斯大学西南医学中心博士后

Postdoctoral Research Fellow, UT Southwestern Medical Center, Dallas, USA

研究概述 Research Description:

中国每年有430万新增癌症患者和280万癌症死亡病例。近年来的环境污染问题进一步加剧了癌症流行，对我们的社会构成了巨大的挑战。 我们实验室的研究兴趣集中于发现和开发新型的抗癌小分子药物。我们的主要研究兴趣包括：（1）使用癌症相关模型发现具有选择性抗癌活性的小分子;（2）使用正向遗传学和化学生物学方法鉴定小分子靶标; （3）发现和研究具有促进致癌蛋白降解功能的天然和人造小分子配体 。我们将结合高通量药物筛选，正向遗传学，化学生物学和生物化学重组，以获得癌症生物学的新见解，并为癌症治疗提供新的和有效的药物。

Cancer is a leading cause of death in China with ~4.3 million new diagnoses and ~2.8 million deaths per year. Chronic exposures to environmental mutagens further exacerbate the cancer epidemic, presenting a great challenge to our society. New and effective cancer treatment strategies are therefore urgently required. Our laboratory is interested in the discovery and development of first-in-class anti-cancer drugs that target previously undruggable proteins. Our research interests include: (1) phenotype based discovery of selective anti-cancer compounds using cancer relevant isogenic models; (2) small molecule target identification using forward genetics and chemical biology methodologies; (3) discovery of natural and artificial small molecule ligands that promote the proteolysis of oncoproteins. We will employ a combination of high throughput drug screening, forward genetics, chemical biology, and biochemical reconstitution to gain new insights in cancer biology and uncover new treatment options for cancer patients.

发表论文 Publications:

1. Lv, L., Chen, P., Cao, L., Li, Y., Zeng, Z., Cui, Y., Wu, Q., Li, J., Wang, J. H., Dong, M. Q., Qi, X., & Han, T. (2020). Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation. Elife, 9. doi:10.7554/eLife.59994

2. Zeng, Z., & Han, T. (2020). Discovering Nature's super glue. Nat Chem Biol, 16(11), 1155-1156. doi:10.1038/s41589-020-0586-x

3. Fuller, G. G., Han, T., Freeberg, M. A., Moresco, J. J., Ghanbari Niaki, A., Roach, N. P., Yates, J. R., 3rd, Myong, S., & Kim, J. K. (2020). RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia. Elife, 9. doi:10.7554/eLife.48480

4. Zhang, J., Li, Z., Zhuo, J., Cui, Y., Han, T., & Li, C. (2019). Tandem Decarboxylative Cyclization/Alkenylation Strategy for Total Syntheses of (+)-Longirabdiol, (-)-Longirabdolactone, and (-)-Effusin. J Am Chem Soc, 141(20), 8372-8380. doi:10.1021/jacs.9b03978

5. Han, T., & Nijhawan, D. (2019). Exome Sequencing of Drug-Resistant Clones for Target Identification. Methods Mol Biol, 1888, 175-187. doi:10.1007/978-1-4939-8891-4_10

6. Han, T., Goralski, M., Gaskill, N., Capota, E., Kim, J., Ting, T. C., Xie, Y., Williams, N. S., & Nijhawan, D. (2017). Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Science, 356(6336). doi:10.1126/science.aal3755

7. Jin, M., Fuller, G. G., Han, T., Yao, Y., Alessi, A. F., Freeberg, M. A., Roach, N. P., Moresco, J. J., Karnovsky, A., Baba, M., Yates, J. R., 3rd, Gitler, A. D., Inoki, K., Klionsky, D. J., & Kim, J. K. (2017). Glycolytic Enzymes Coalesce in G Bodies under Hypoxic Stress. Cell Rep, 20(4), 895-908. doi:10.1016/j.celrep.2017.06.082

8. Han, T., & Kim, J. K. (2016). Mapping the Transcriptome-Wide Landscape of RBP Binding Sites Using gPAR-CLIP-seq: Experimental Procedures. Methods Mol Biol, 1361, 77-90. doi:10.1007/978-1-4939-3079-1_5

9. Han, T., Goralski, M., Capota, E., Padrick, S. B., Kim, J., Xie, Y., & Nijhawan, D. (2016). The antitumor toxin CD437 is a direct inhibitor of DNA polymerase alpha. Nat Chem Biol, 12(7), 511-515. doi:10.1038/nchembio.2082

10. Alessi, A. F., Khivansara, V., Han, T., Freeberg, M. A., Moresco, J. J., Tu, P. G., Montoye, E., Yates, J. R., 3rd, Karp, X., & Kim, J. K. (2015). Casein kinase II promotes target silencing by miRISC through direct phosphorylation of the DEAD-box RNA helicase CGH-1. Proc Natl Acad Sci U S A, 112(52), E7213-7222. doi:10.1073/pnas.1509499112

11. Wang, G., Han, T., Nijhawan, D., Theodoropoulos, P., Naidoo, J., Yadavalli, S., Mirzaei, H., Pieper, A. A., Ready, J. M., & McKnight, S. L. (2014). P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell, 158(6), 1324-1334. doi:10.1016/j.cell.2014.07.040

12. Han, T., & Kim, J. K. (2014). Driving glioblastoma growth by alternative polyadenylation. Cell Res, 24(9), 1023-1024. doi:10.1038/cr.2014.88

13. Freeberg, M. A., Han, T., Moresco, J. J., Kong, A., Yang, Y. C., Lu, Z. J., Yates, J. R., & Kim, J. K. (2013). Pervasive and dynamic protein binding sites of the mRNA transcriptome in Saccharomyces cerevisiae. Genome Biol, 14(2), R13. doi:10.1186/gb-2013-14-2-r13 doi:10.1371/journal.pgen.1002617

14. Billi, A. C., Alessi, A. F., Khivansara, V., Han, T., Freeberg, M., Mitani, S., & Kim, J. K. (2012). The Caenorhabditis elegans HEN1 ortholog, HENN-1, methylates and stabilizes select subclasses of germline small RNAs. PLoS Genet, 8(4), e1002617.

15. Zhao, W., Feng, D., Sun, S., Han, T., & Sui, S. (2010). The anti-viral protein of trichosanthin penetrates into human immunodeficiency virus type 1. Acta Biochim Biophys Sin (Shanghai), 42(2), 91-97. doi:10.1093/abbs/gmp111

16. Mangone, M., Manoharan, A. P., Thierry-Mieg, D., Thierry-Mieg, J., Han, T., Mackowiak, S. D., Mis, E., Zegar, C., Gutwein, M. R., Khivansara, V., Attie, O., Chen, K., Salehi-Ashtiani, K., Vidal, M., Harkins, T. T., Bouffard, P., Suzuki, Y., Sugano, S., Kohara, Y., Rajewsky, N., Piano, F., Gunsalus, K. C., & Kim, J. K. (2010). The landscape of C. elegans 3'UTRs. Science, 329(5990), 432-435. doi:10.1126/science.1191244

17. Gerstein, M. B., et al. (2010). Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science, 330(6012), 1775-1787. doi:10.1126/science.1196914

18. Han, T., Manoharan, A. P., Harkins, T. T., Bouffard, P., Fitzpatrick, C., Chu, D. S., Thierry-Mieg, D., Thierry-Mieg, J., & Kim, J. K. (2009). 26G endo-siRNAs regulate spermatogenic and zygotic gene expression in Caenorhabditis elegans. Proc Natl Acad Sci U S A, 106(44), 18674-18679. doi:10.1073/pnas.0906378106

19. Friedlander, M. R., Adamidi, C., Han, T., Lebedeva, S., Isenbarger, T. A., Hirst, M., Marra, M., Nusbaum, C., Lee, W. L., Jenkin, J. C., Sanchez Alvarado, A., Kim, J. K., & Rajewsky, N. (2009). High-resolution profiling and discovery of planarian small RNAs. Proc Natl Acad Sci U S A, 106(28), 11546-11551. doi:10.1073/pnas.0905222106

20. Li, S., Liu, C., Li, N., Hao, T., Han, T., Hill, D. E., Vidal, M., & Lin, J. D. (2008). Genome-wide coactivation analysis of PGC-1alpha identifies BAF60a as a regulator of hepatic lipid metabolism. Cell Metab, 8(2), 105-117. doi:10.1016/j.cmet.2008.06.013

Invited book chapters and review articles:

1. Han, T., and Nijhawan, D. Exome Sequencing of Drug-resistant Clones for Target Identification.Methods Mol Biol(in press)

2. Han, T., and Kim, J.K. (2016). Mapping the Transcriptome-Wide Landscape of RBP Binding Sites Using gPAR-CLIP-seq: Experimental Procedures.Methods Mol Biol 1361, 77-90.

3. Han, T., and Kim, J.K. (2014). Driving glioblastoma growth by alternative polyadenylation.Cell Res 24, 1023-1024.