袭荣文博士

清华大学生物医学交叉研究院教授，北京生命科学研究所资深研究员

Rongwen Xi, Ph.D. Professor, TIMBR Investigator, NIBS, Beijing, China

教育经历 Education

2002

美国肯塔基州大学生物学博士

Ph.D. in Biology,2002，University of Kentucky,USA

1998

上海医科大学 理科硕士

Master in Science, 1998，Shanghai Medical University, China

1995

滨州医学院 临床医药学学士

B.S., Department ofClinical Medicine,1995，Binzhou Medical College,China

工作经历 Professional Experience

2018-

清华大学生物医学交叉研究院教授，北京生命科学研究所资深研究员

Investigator, National Institute of Biological Sciences, Professor, TIMBR, Beijing, China

2011-2018

北京生命科学研究所高级研究员

Associate Investigator, National Institute of Biological Sciences, Beijing, China

2006-2011

北京生命科学研究所研究员

Assistant Investigator, National Institute of Biological Sciences, Beijing, China

2003-2006

美国思达沃医学研究所博士后

Postdoctoral Research Associate with Dr. Ting Xie at the Stowers Institute for Medical Research, USA

1998-2002

美国肯塔基州大学生物系助教，助研

Teaching Assistant, Research Assistant at the Department of Biology,University of Kentucky, USA

研究概述

成体干细胞长期存在于多种组织和器官内，通过不断的自我更新和分化，维持组织细胞的新旧更替。干细胞功能的失调可能导致癌症或退行性病变等疾病的发生，但我们对干细胞增殖和分化时细胞的命运抉择等行为的分子调控机制还没有清楚的理解。我们结合相对简单的遗传模式生物果蝇及哺乳动物模型，以肠道干细胞为主要研究对象，研究干细胞自我更新和多个细胞谱系分化过程中命运决定的内源性机制及环境调控机制，及肠上皮细胞的分化和功能调节机制及它们在脑-肠-肠道菌群轴中所扮演的角色。我们的研究将最终为肠道肿瘤、代谢性疾病等肠道相关疾病的防治提供理论依据和试验基础。

Research Description

Adult stem cells reside in many tissues and organs and have the ability to self-renew indefinitely and generate progenies that differentiate and replace aged and damaged cells. Dysregulation of stem cells is intimately associated with various types of diseases such as cancer and degenerative diseases, but the molecular mechanisms regulating stem cell fate decisions during self-renewal and cell lineage differentiation are in general poorly understood. Using intestinal stem cell systems in both flies and mice, we aim to understand the intrinsic and extrinsic mechanisms underlying stem cell fate decisions, and the differentiation and functional regulation of intestinal cells and their roles played in the brain-gut-microbiota axis. Our research should ultimately bring new mechanistic insights into intestinal tumors and other digestive and metabolic diseases and pave the way to new treatments.

发表文章

Publications:

1. Zhu G, Hu J,Xi R* (2021). The cellular niche for intestinal stem cells: a team effort.Cell Regen. 10(1):1.

2. Shi J, Jin Z, Yu Y, Zhang Y, Yang F, Huang H, Cai T,Xi R* (2021). A Progressive Somatic Cell Niche Regulates Germline Cyst Differentiation in the Drosophila Ovary.Curr Biol. 31(4):840-852.e5.

3. Jin Z, Chen J, Huang H, Wang J, Lv J, Yu M, Guo X, Zhang Y, Cai T,Xi R*(2020). The Drosophila Ortholog of Mammalian Transcription Factor Sox9 Regulates Intestinal Homeostasis and Regeneration at an Appropriate Level.Cell Rep. 31(8):107683.

4. Kobayashi M, Lin Y, Mishra A, Shelly C, Gao R, Reeh CW, Wang PZ,Xi R, Liu Y, Wenzel P, Ghosn E, Liu Y, Yoshimoto M (2020). Bmi1 Maintains the Self-Renewal Property of Innate-like B Lymphocytes.J Immunol. 204(12):3262-3272.

5. Li Z, Guo X, Huang H, Wang C, Yang F, Zhang Y, Wang J, Han L, Jin Z, Cai T,Xi R*(2020). A Switch in Tissue Stem Cell Identity Causes Neuroendocrine Tumors in Drosophila Gut.Cell Rep. 30(6):1724-1734.e4.

6. Guo X, Yin C, Yang F, Zhang Y, Huang H, Wang J, Deng B, Cai T, Rao Y,Xi R*(2019). The Cellular Diversity and Transcription Factor Code of Drosophila Enteroendocrine Cells.Cell Rep. 29(12):4172-4185.e5.

7. Guo X, Huang H, Yang Z, Cai T,Xi R* (2019). Division of Labor: Roles of Groucho and CtBP in Notch-Mediated Lateral Inhibition that Controls Intestinal Stem Cell Differentiation in Drosophila.Stem Cell Reports. 12(5):1007-1023

8. Yang F*, Quan Z, Huang H, He M, Liu X, Cai T, andXi R* (2019). Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing.Elife2019 Jan 16;8. pii: e40806.

9. Zhang W, Zhang X, Xue Z, Li Y, Ma Q, Ren X, Zhang J, Yang S, Yang L, Wu M, Ren M,Xi R, Wu Z, Liu JL, Matunis E, Dai J, Gao G (2018). Probing the Function of Metazoan Histones with a Systematic Library of H3 and H4 Mutants.Dev Cell. pii: S1534-5807(18)31031-1.

10. Chen J, Xu N, Wang C, Huang P, Huang H, Jin Z, Yu Z, Cai T, Jiao R,Xi R*(2018). Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells.Nat Cell Biol.20(2):152-161

11. Yin C,Xi R*(2018). A Phyllopod-Mediated Feedback Loop Promotes Intestinal Stem Cell Enteroendocrine Commitment in Drosophila.Stem Cell Reports.9;10(1):43-57.

12. Huang C, Yang F, Zhang Z, Zhang J, Cai G, Li L, Zheng Y, Chen S,Xi R*, Zhu B*(2017). Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila.Nat Commun.8(1):1649.

13. Liu X, Wei W, Li X, Shen P, Ju D, Wang Z, Zhang R, Yang F, Chen C, Cao K, Zhu G, Chen H, Chen L, Sui J, Zhang E, Wu K, Wang F, Zhao L,Xi R*(2017). BMI1 and MEL18 Promote Colitis-Associated Cancer in Mice via REG3B and STAT3.Gastroenterology. pii: S0016-5085(17)35976-0.

14. Li Y*, Pang Z, Huang H, Wang C, Cai T,Xi R*(2017). Transcription Factor Antagonism Controls Enteroendocrine Cell Specification from Intestinal Stem Cells.Sci Rep.20;7(1):988.

15. Yang F,Xi R*(2017). Silencing transposable elements in the Drosophila germline.Cell Mol Life Sci.74(3):435-448.

16. Chen J., Li J., Huang H. andXi R*. (2016). Gene Expression Analysis of Sorted Cells by RNA-seq in Drosophila Intestine.Bio-protocol6(24): e2079. DOI: 10.21769/BioProtoc.2079

17. Li X, Yang F, Chen H, Deng B, Li X,Xi R*(2016). Control of germline stem cell differentiation by polycomb and trithorax group genes in the niche microenvironment.Development. 143(19):3449-3458 pii: dev.137638.

18. Chen J, Xu N, Huang H, Cai T,Xi R*(2016). A feedback amplification loop between stem cells and their progeny promotes tissue regeneration and tumorigenesis.Elife. 5. pii: e14330. doi: 10.7554/eLife.14330

19. Wang C,Xi R*(2015). Keeping intestinal stem cell differentiation on the Tramtrack.Fly(Austin). 14:0.

20. Hu Z, Hu Y, Liu X,Xi R, Zhang A, Liu D, Xie Q, Chen L (2015). Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor.Oncotarget. 6(31):31628-39

21. Wang C, Guo X, Dou K, Chen H,Xi R*(2015). Ttk69 acts as a master repressor of enteroendocrine cell specification in Drosophila intestinal stem cell lineages.Development142(19):3321-31

22. Yang F, Zhao R, Fang X, Huang H, Xuan Y, Ma Y, Chen H, Cai T, Qi Y,Xi R*(2015). The RNA surveillance complex Pelo-Hbs1 is required for transposon silencing in the Drosophila germline.EMBO Rep. 16(8):965-74

23. Wang C, Guo X,Xi R*(2014). EGFR and Notch signaling respectively regulate proliferative activity and multiple cell lineage differentiation of Drosophila gastric stem cells.Cell Research24(5):610-27

24. Quan Z, Sun P, Lin G,Xi R*(2013). TSC1/2 regulates intestinal stem cell maintenance and lineage differentiation via Rheb-TORC1-S6K but independent of nutrition status or Notch regulation.J Cell Sci. 126:3884-92

25. Wang C, Zhao R, Huang P, Yang F, Quan Z, Xu N,Xi R*(2013). APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression.Developmental Biology378(2):122-40

26. Lin G, Zhang X, Ren J, Pang Z, Wang C, Xu N,Xi R*(2013). Integrin signaling is required for maintenance and proliferation of intestinal stem cells in Drosophila.Developmental Biology377(1):177-87

27. Wen P, Quan Z,Xi R*(2012). The biological function of the WD40 repeat-containing protein p55/Caf1 in Drosophila.Developmental Dynamics241(3):455-64

28. Xu N, Wang SQ, Tan D, Gao Y, Lin G,Xi R*(2011). EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells.Developmental Biology354(1):31-43

29. Su Y, Deng B,Xi R*(2011). Polycomb group genes in stem cell self-renewal: a double-edged sword.Epigenetics. 6(1):16-9.

30. Sun P, Quan Z, Zhang, B, Wu T,Xi R*(2010). TSC1/2 tumour suppressor complex maintains Drosophila germline stem cells by preventing differentiation.Development137(15):2461-9

31. Wen P, Sun P,Xi R* (2010). Stem cell niche (book chapter) in “Regenerative Medicine – From Protocol to Patient”. The Springer Press.

32. Li X, Han Y,Xi R*(2010). Polycomb group genes Psc and Su(z)2 restrict follicle stem cell self-renewal and extrusion by controlling canonical and noncanonical Wnt signaling.Genes & Development24(9):933-46.

33. Zhao R,Xi R*(2010). Stem Cell Competition for Niche Occupancy: Emerging Themes and Mechanisms.Stem Cell Rev. 6(3):345-50

34. Lin G, Xu N,Xi R*(2010). Paracrine unpaired signaling through the JAK/STAT pathway controls self-renewal and lineage differentiation of drosophila intestinal stem cells.J Mol Cell Biol2(1): 37-49.

35.Xi, R*(2009). Anchoring stem cells in the niche by cell adhesion molecules.Cell Adh Migr3(4): 396-401.

36.Lin G,Xi R*(2008) Intestinal stem cell, muscular niche and wingless signaling.Fly(Austin). 2(6): 310-2.

37. Lin G, Xu N,Xi R* (2008). Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells.Nature455(7216):1119-23.

38. Zhao R, Xuan Y, Li X,Xi R*(2008). Age-related changes of germline stem cell activity, niche signaling activity and egg production in Drosophila.Aging Cell7(3):344-54

39.Xi R, Xie T (2005). Stem cell self-renewal controlled by chromatin remodeling factors.Science310(5753):1487-9.

40.Xi R, Doan C, Liu D, Xie T (2005). Pelota controls self-renewal of germline stem cells by repressing a bam-independent differentiation pathway.Development132(24):5365-74.

41.Xi R, Kirrily D, Xie T (2005). Molecular mechanisms controlling germline and somatic stem cells: similarities and differences (review).Curr Opin Genet Dev. 15(4):381-7.

42. Rawlings JS, Rennebeck G, Harrison SM,Xi R, Harrison DA (2004). Two Drosophila Suppressors of Cytokine Signaling (SOCS) differentially regulate JAK and EGFR pathway activities.BMC Cell Biol. 15;5(1):38.

43. Song X, Wong, MD, Kawase E,Xi R, Ding BC, McCarthy J, Xie T (2004). BMP signaling from the niche directly represses the transcription of a differentiating gene, bag of marbles, in the germline stem cells of Drosophila ovary.Development131(6):1353-64.

44.Xi R, McGregor JR, Harrison DA (2003). A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium.Developmental Cell4(2):167-77.

45.McGregor JR,Xi R, Harrison DA (2002). JAK signaling is somatically required for follicle cell differentiation in Drosophila.Development129(3):705-17.