邮箱:suijianhua@nibs.ac.cn

电话:86-10-80726688-8630

Fax:86-10-80726021

  • 隋建华博士

    清华大学生物医学交叉研究院助理教授,北京生命科学研究所研究员,生物制品中心和抗体中心主任

    Jianhua Sui, Ph.D. Assistant Professor, TIMBR, Assistant Investigator & Director of Biologics Center, NIBS, Beijing, China

  • 教育经历: Education

    2000

    中国协和医科大学中国医学科学院 血液学研究所 病理生理学博士

    Ph.D. Pathophysiology, Institute of Hematology, Peking Union Medical College & Chinese Academy of Medical Sciences, China

    1997

    兰州大学医学院心血管内科学硕士

    M.S. Cardiovascology, Lanzhou Medical School, Lanzhou University, China

    1994

    兰州大学医学院 临床医学学士

    B.S. Clinical Medicine, Lanzhou Medical School, Lanzhou University, China

  • 工作经历 Professional Experience

    2012–

    清华大学生物医学交叉研究院助理教授,北京生命科学研究所研究员,生物制品中心主任

    Assistant Professor, TIMBR, Assistant Investigator and Director of Biologics Research Center National Institute of Biological Sciences, Beijing, China

    2004–2011

    哈佛大学 医学院Dana-Farber癌症研究所 讲师

    Instructor Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, US

    2000–2004

    哈佛大学 医学院Dana-Farber癌症研究所 博士后

    Postdoctoral Fellow Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, US

  • 研究概述 Research Description

    我们实验室/生物制品中心以重要感染性疾病,恶性肿瘤及自身免疫疾病为研究对象,将基础生物学研究与医学应用相结合,开展以治疗性抗体为主的相关研究。主要包括:1)发现和确认新型治疗性靶分子; 2)开发治疗性人源抗体; 3)发展新型抗体工程技术; 4)以抗体为主的生物大分子制备和抗体新药临床前研究及评估等。

    Our laboratory and the Biologics Research Center conduct human antibody related researches at the intersection of biology and medicine. We take interdisciplinary approaches to develop innovative biologics for diseases prevention and therapy, mainly focus on infectious diseases, cancer andautoimmune diseases. Research programs include: 1) identification and validation of novel therapeutic targets; 2) development of therapeutic human monoclonal antibodies; 3) develop new antibody engineering technologies; 4) biologics production and pre-clinical validation of new antibody drugs, etc.

  • 部分发表文章 SelectedPublications(*Corresponding or co-corresponding author)

    1. Li Y,Liu J,Chen W,Wang W,Yang F,Liu X,Sheng Y,Du K,He M,Lü X, Li H,Zhao L,Wei Z,Wang F,Zheng S,Sui J*. A pH-dependent anti-CD47 antibody that selectively targets solid tumors and improves therapeutic efficacy and safety.J Hematol Oncol2023, 16 (1) : 2.

    2. Tian X,Liu X,Ding J,Wang F,Wang K,Liu J,Wei Z,Hao X,Li Y,Wei X,Zhang H,Sui J*. An anti-CD98 antibody displaying pH-dependent Fc-mediated tumour-specific activity against multiple cancers in CD98-humanized mice.Nat Biomed Eng2023, 7 (1) : 8-23.

    3. Liu X,Tian X, Hao X, Zhang H, Wang K,Wei Z,Wei X,Li Y,Sui J*. A cross-reactive pH-dependent EGFR antibody with improved tumor selectivity and penetration obtained by structure-guided engineering.Mol Ther Oncolytics2022, 27 : 256-269.

    4. Du K, Li Y, Liu J, Chen W, Wei Z, Luo Y, Liu H, Qi Y, Wang F,Sui J*. A bispecific antibody targeting GPC3 and CD47 induced enhanced antitumor efficacy against dual antigen-expressing HCC.Mol Ther2021, 29 (4) : 1572-1584

    5.Yang F, Zhao L, Wei Z, Yang Y, Liu J, Li Y, Tian X, Liu X, , andSui J*. A Cross-Species Reactive TIGIT-Blocking Antibody Fc Dependently Confers Potent Antitumor Effects.J Immunol2020,205(8): 2156-2168

    6. Li SB, Liu YY, Yuan L, Ji MF, Zhang A, Li HY, Tang LQ, Fang SG, Zhang H, Xing S, Li MZ, Zhong Q, Lin SJ, Liu WL, Huang P, Zeng YX, Zheng YM, Ling ZQ,Sui JH, Zeng MS. 2020. Autocrine INSL5 promotes tumor progression and glycolysis via activation of STAT5 signaling.EMBO Mol Med: e12050

    7. Liu H, Zheng S, Hou X, Liu X, Du K, Lv X, Li Y, Yang F, Li W,Sui J*. Novel antibodies targeting the N-terminus of FGF19 inhibit hepatocellular carcinoma growth without bile-acid-related side effects.Can Sci2020,111(5):1750-1760

    8.Qiao L,Sui J, Luo G. Robust Human and Murine Hepatocyte Culture Models of Hepatitis B Virus Infection and Replication.J Virol2018, 92 (23).

    9. Li D, He W, Liu X, Zheng S, Qi Y, Li H, Mao F, Liu J, Sun Y, Pan L, Du K, Ye K, Li W,Sui J*. A potent human neutralizing antibody Fc-dependently reduces established HBV infections. eLife2017, 6: e26738.

    10. Kang J, Wang J, Cheng J, Cao Z, Chen R, Li H, Liu S, Chen X,Sui J*, Lu F. Down-regulation of NTCP expression by cyclin D1 in hepatitis B virus-related hepatocellular carcinoma has clinical significance.Oncotarget2017;8(34):56041-56050.

    11. He W, Cao Z, Mao F, Ren J, Li Y, Li D, Li H, Peng B, Yan H, Qi Y, Sun Y, Wang F,Sui J*, Li W. Three amino acids modification in sodium taurocholate cotransporting polypeptide renders mice susceptible for infection of hepatitis D virus In vivo.JVirol2016, 90 (19), 8866-74.

    12. Huang X, Dong W, Milewska A, Golda A, Qi Y, Zhu QK, Marasco WA, Baric RS, Sims AC, Pyrc K, Li W,Sui J*. HCoV-HKU1 Spike protein uses O-acetylated sialic acid as an attachment receptor determinant and employs HE protein as a receptor-destroying enzyme.J Virol2015, 89 (14), 7202-7213.

    13.Sui J, Deming M, Rockx B, Liddington RC, Zhu QK, Baric RS, Marasco WA. Effects of human anti-spike protein receptor binding domain antibodies on severe acute respiratory syndrome coronavirus neutralization escape and fitness.J Virol2014, 88 (23), 13769-80.

    14. DK Chang,Sui J, Geng S, Muvaffak A, Bai M, Fuhlbrigge R, Lo A, Yammanuru A, Hubbard L, Sheehan J, Campbell J, Zhu Q, Kupper T, Marasco WA. Humanization of an anti-CCR4 antibody that killscutaneous Tcelllymphoma cells and abrogates suppression by T regulatory cells.Molecular Cancer Therapeutics2012,11 (11):2451-61.

    15. Yan H, Zhong G, Xu G, He W, Jing Z, Gao Z, Huang Y, Qi Y, Peng B, Wang H, Fu L, Song M, Chen P, Gao W, Ren B, Sun Y, Cai T, Feng X,Sui J, Li W. 2012. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus.eLife2012, 1:e00049.

    16.Sui J, Sheehan J, Hwang WC, Bankston LA, Burchett SK, Huang CY, Liddington RC, Beigel JH, Marasco WA. Wideprevalence ofheterosubtypicbroadlyneutralizinghumananti-Influenza Aantibodies.Clin Infect Dis2011, 52 (8):1003-1009

    17.Sui J*, Hwang WC, Perez S, Wei G, Aird D, Chen L, Santelli E, Stec B, Cadwell G, Ali M, Murakami A, Yammanuru A, Han T, Cox N, Bankston LA, Donis RO, Liddington RC and Marasco WA. Structural andfunctionalbasis forbroad-spectrumneutralization ofavian andhumaninfluenza Aviruses.Nat Struct Mol Biol2009, 16(3):265-73.

    Commentsin Nat Biotech, Nat Struct Mol Bio and Nat Med2009.

    18.Sui J*, Aird DR, Tamin A, Murakami A, Yan M, Yammanur, A, Jing H, Kan B, Liu, X, Zhu Q, Yuan Q, Adams GP, Bellini WJ, Xu J, Anderson LJ and Marasco WA. Broadening ofneutralizationactivity todirectlyblock adominantantibody-driven SARS-Coronavirusevolutionpathway.Plos Pathogen2008, 4(11):e1000197.

    19. Marasco WA,Sui J*. The growth and potential of human anti-viral monoclonal antibody therapeutics.Nature Biotechnology(Invited Review)2007, 25(12):1421-34.

    20. Xu C,Sui J, Tao H, Zhu Q, Wayne A. Marasco. Human anti-CXCR4 antibodies undergo VH replacement, exhibit functional V-Region sulfation and define CXCR4 antigenic heterogeneity.J Immunol2007,179(4):2408-18

    21.Sui J,Li W, Roberts A, Matthews LJ, Murakami A, Vogel L, Wong SK, Subbarao K, Farzan M, Marasco WA. Evaluation of humanMab 80r for immunoprophylaxis of SARS by an animal study, epitope mapping and analysis of spike variants.J Virol2005, 79(10):5900-5906.

    22. Bai J,Sui J, Demirjian A, Vollmer Jr CM, Marasco WA, Callery MP. Predominant Bcl-XL knockdown disables antiapoptotic mechanisms: tumor necrosis factor-related apoptosis-inducing ligand-based triple chemotherapy overcomes chemoresistance in pancreatic cancer cells in Vitro.Cancer Res2005, 65(6):2344-2352

    23.Sui J, Li W, Murakami A, Tamin A, Matthews LJ, Wong SK, Moore MJ, Tallrico AS, Olurinde M, Choe H, Anderson LJ, Bellini WJ, Farzan M, and Marasco WA. Potent neutralization of SARS coronavirus Infection by a human monoclonal antibody against the ACE2-binding domain of spike protein.Proc Natl Acad Sci USA2004,101(8):2536-41.

    24.Sui J,Marasco WA. Evidence against Ebola virus sGP binding to human neutrophils by a specific receptor.Virology2002, 303(1):9-14.

  • 专利 Patents

    1.SuiJ, Liu H. Anti-FGF19 antibodies. Patent No. US222/0041706A1. 2022

    2.Sui J, Li D, Li W. Anti-PreS1-HBV Antibodies. Patent No. US10544205B2. 2020

    3. Marasco WA,Sui J. Human monoclonal anti-PD-L1 antibodies and methods of use. PatentNo.: US10604581B2. 2020

    4.Marasco WA,Sui J, Zhu Q, Kupper T. Affinity matured anti-CCR4 humanized monoclonal antibodies and methods of use. Patent No. US9441045B2;JP6411329B2. 2018

    5.Marasco WA,Sui J. Antibodies against H5N1 and methods of use thereof. Patent No. EP2222701B1;JP6149213B2;CA2708221C. 2017

    6.Marasco WA,Sui J, Anvir Y. Humanized monoclonal antibodies and methods of use. Patent No. US9527924B2;EP2575882B1. 2016

    7. Marasco WA,Sui J, Zhu Q, Kupper T. Humanized monoclonal antibodies and methods of use. Patent No. US9416169. 2016

    8. Marasco WA,Sui J, Xu C. Antibodies against CXCR4 and methods of Use Thereof. Patent No. US8329178 B2; EP1871807 B1; CA2597717C. 2012

    9. Marasco WA,Sui J. Antibodies against SARS-COV and methods of use thereof. Patent No. US7750123. 2010