王涛博士

清华大学生物医学交叉研究院副教授，北京生命科学研究所高级研究员

Tao Wang, Ph.D. Associate Professor, TIMBR, Associate Investigator, NIBS, Beijing, China

教育经历 Education

2006年美国约翰霍普金斯大学医学院生物化学系，博士

Ph. D.,Department of Biological Chemistry, Johns Hopkins University,Baltimore, MD, USA

2000年 北京大学生物化学系，硕士

M.S.,Biochemistry Department, Peking University, Beijing, P. R. China

1997年 南开大学生物化学及分子生物学系，学士

B.S.,Biochemistry and Molecular Biology Department, Nankai University, Tianjin, P. R. China

工作经历

2018-

清华大学生物医学交叉研究院副教授，北京生命科学研究所高级研究员

Associate Professor, TIMBR, Associate Investigator, National Institute of Biological Sciences, Beijing, China

2012-2018

北京生命科学研究所研究员

Assistant Investigator, National Institute of Biological Sciences, Beijing, China

2007-2011

美国Fred Hutchinson癌症研究中心，博士后

Postdoctoral Fellow, Division of Basic Science Fred Hutchinson Cancer Research Center, Seattle, WA, USA

2006-2007

美国约翰霍普金斯大学，博士后

Postdoctoral Fellow, Department of Biological Chemistry, Johns Hopkins University, Baltimore, USA

研究概述

细胞内各个细胞器包括内质网、线粒体和胞浆都存在质量控制机制，破坏质量控制的任何环节都会影响细胞稳态，是细胞功能丧失。我们的实验室致力于以果蝇模型为主研究细胞器内质量控制的分子机制；各个质量控制系统之间的协调互作以维持细胞健康。

1.线粒体运输协同线粒体自噬维持了神经元轴突中线粒体稳态，对神经元的生长和生理功能维持至关重要。围绕线粒体的质量控制机制，我们的实验室致力于揭示线粒体选择性顺行和逆行运输的分子机制；线粒体自噬及调控网络，并在果蝇、小鼠、以及人源细胞等多种研究模式中研究线粒体质量控制对神经元生理功能维持的生理意义。

2.细胞磷脂代谢依赖于线粒体和内质网之间的脂质双向交换，多种磷脂如磷脂酰乙醇胺的缺乏引起多重应激信号。我们实验室致力于探索线粒体和内质网之间脂质双向交换的分子机制和生理功能，进而对细胞器之间如何协同反应以对抗各种压力。

3.诸如多聚谷氨酰胺病等主要神经退行性疾病都与错误折叠蛋白质的聚集有关。我们实验室利用胞浆和内质网错误折叠蛋白质引发神经元退变的果蝇模型，深入探讨细胞如何感知错误折叠蛋白质，错误折叠蛋白在聚集前和聚集后的清除的机制，以及生物体如何在蛋白高度聚集时引发细胞死亡并清除异常细胞。

发表文章

1. Xie J., Han Y. andWang T.*2021. RACK1 modulates polyglutamine-induced neurodegeneration by promoting ERK degradation in Drosophila.PLoS Genet. 17(5):e1009558.

2. Han Y., Zhuang N. andWang T.*2021. Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila.Cell Reports. 34(12):108875(cover article).

3. Xu J., Zhao H. andWang T.*2020. Suppression of retinal degeneration by two novel ERAD ubiquitin E3 ligases SORDD1/2 in Drosophila.PLoS Genet. 16(11):e1009172.

4. Zhao H. andWang T.*2020. PE homeostasis rebalanced through mitochondria-ER lipid exchange prevents retinal degeneration in Drosophila.PLoS Genet. 16(10):e1009070.

5. Xiong L., Zhang L., Yang Y., Li N., Lai W., Wang F., Zhu X. andWang T.*. 2020. ER complex proteins are required for rhodopsin biosynthesis and photoreceptor survival in Drosophila and mice. Cell Death Differ.27(2): 646-661.

6. Xu Y. andWang T.*2019. LOVIT Is a Putative Vesicular Histamine Transporter Required in Drosophila for Vision.Cell Rep. 27(5):1327-1333.

7. Zhao H., Wang J. andWang T.*2018. The V-ATPase V1 subunit A1 Is required for rhodopsin anterograde trafficking inDrosophila.Mol. Biol. Cell. 29(13):1640-1651.(cover article).

8. Ren S., Huang Z., Jiang Y. andWang T.*2018. dTBC1D7 regulates systemic growth independently of TSC through insulin signaling.J. Cell Biol.217(2):517-526.

9. Han Y., Xiong L., Xu Y., Tian T. andWang T.*2017. The β-alanine transporter BalaT is required for visual neurotransmission inDrosophila.Elife.6:e29146.

10. Zhuang N., Li L., Chen S. andWang T.*2016.PINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control.Cell Death Dis.7(12):e2501.

11. Huang Z., Ren S., Jiang Y. andWang T.*2016. PINK1 and Parkin cooperatively protect neurons against constitutively active TRP channel-induced retinal degeneration inDrosophila.Cell Death Dis.7:e2179

12. Xu Y. andWang T.*2016. CULD is required for rhodopsin and TRPL channel endocytic trafficking and survival of photoreceptor cells.J Cell Sci. 15;129(2):394-405.

13. Xu Y., An F., Borycz J.A., Borycz J., Meinertzhagen I.A. andWang T.*2015. Histamine Recycling Is Mediated by CarT, a Carcinine Transporter inDrosophilaPhotoreceptors.PLoS Genet. 11(12):e1005764.

14. Kuo Y., Hang H., Cai T. andWang T.*2015. Target of Rapamycin Complex 2 regulates cell growth via Myc inDrosophila.Sci. Rep.5:10339.

15. Huang Y., Xie J. andWang T.*2015. A Fluorescence-Based Genetic Screen to Study Retinal Degeneration inDrosophila.PLoS One. 10(12):e0144925.

16. Wu K., Liu J., Zhuang N. andWang T.*2014. UCP4A protects against mitochondrial dysfunction and degeneration in pink1/parkin models of Parkinson's disease.FASEB Journal.28(12):5111-21

17. Kuo Y., Ren S., Lao U., Edgar B.A., Wang T.* 2013. Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110.Cell Death Dis. 3;4:e833.

18.Wang T.*,Blumhagen R., Lao U. Kuo Y. and Edgar B.A. 2012. LST8 regulates cell growth via Target-of-Rapamycin Complex2.Mol. Cell. Biol. 32(12):2203-2213 (cover article).

19. Wang T., WangX., Ni J., Von Lintig J. and Montell C.* 2012. TheDrosophilavisual cycle andde novochromophore synthesis depends onrdhB.J Neurosci.32: 3485-3491.

20.Wang X.,Wang T., Jiao Y., Von Lintig J. and Montell C.* 2010. Requirement for an Enzymatic Visual Cycle inDrosophila.Curr. Biol. 20:93-102 (equal contribution of first two authors)

21. Wang T.* and Edgar B.A.* 2010. TOR signaling and cell death. The Enzymes.28: 217-244 (Book Chapter)

22. Wang T., Lao U. and Edgar B.A. 2009. TOR-mediated autophagy regulates cell death inDrosophilaneurodegenerative disease.J. Cell Biol.186: 703-711

23.Wang T., Wang X., Xie Q. and Montell C.* 2008. The SOCS box protein STOPS is required for phototransduction through its effects on phospholipase C.Neuron.57,56-68(Cover article).

24. Liu Z., Wang X., Yu Y., Li X., Wang T., Jiang H., Ren Q., Jiao Y., Sawa A., Moran T., Ross CA., Montell C. and Smith W.W.* 2008. ADrosophilamodel for LRRK2-linked parkinsonism.Proc. Natl. Acad. Sci. USA. 105, 2693-2698

25.Wang T.and Montell C.* 2007. Phototransduction and retinal degeneration inDrosophila.Pflugers Arch.454, 821-847. (review)

26.Liu C-H.Wang T.Postma M. Obukhov A.G. Montell C. and Hardie R.C.* 2007.In vivoidentification and manipulation of the Ca²⁺selectivity filter in theDrosophilaTRP channel.J Neurosci.27,604-615(equal contribution of first two authors).

27.Wang T., Jiao Y. and Montell C.* 2007. Dissection of the pathway required for generation of vitamin A and forDrosophilaphototransduction.J Cell Biol.177,305-316.

28.Wang T.and Montell C.* 2006. A PI Synthase Required for a Sustained Light Response.J Neurosci.26,12816-12825.

29.Wang T., Jiao Y. and Montell C.* 2005. Dissecting independent channel and scaffolding roles of theDrosophilaTRP channel.J. Cell Biol.171, 685-694.

30.Wang T.and Montell C.* 2005. Rhodopsin formation inDrosophilais dependent on the PINTA retinoid binding protein.J. Neurosci.25, 5187-5194 (Cover article).

31.Wang T., Xu H., Oberwinkler J., Gu Y., Hardie R.C. and Montell C.* 2005. Light-activation, adaptation and cell survival functions of the Na⁺/Ca²⁺exchanger, CalXNeuron45, 367-378.