饶毅 博士

北京生命科学研究所资深研究员

北京大学终身讲席教授、生命科学学院院长

Yi Rao, Ph.D. Investigator , NIBS, Beijing, China

Peking University Chair

Professor Dean, Peking University School of Life Sciences

Phone：010-80726672;80726688-8368

Fax： 010-80726673

E-mail：yrao@pku.edu.cn

教育经历

Education

工作经历

Professional Experience

研究概述

Research Description

本实验室主要兴趣在于：社会行为的分子和细胞机理。

社会行为是动物针对同种属动物的行为，其范围从动物的相互作用到人类的社会交往、政治、战争。

本实验室通过多学科交叉，用分子生物学、遗传学、神经生物学、心理学、化学分析、现代成像和电生理等综合途径，研究重要和基本社会行为。

主要研究果蝇、小鼠和人。

在果蝇和小鼠，目前集中研究争斗、求偶、和母性行为。用可定量的实验模型，检测行为的模式和变化。用分子生物学和遗传学方法，在一定空间和时间规范基因的活性（双规基因）、在特定时间和区域控制神经活动（双规神经细胞），以确立脑中参与特定行为的区域、神经细胞和分子，希望理解执行特定行为需要的分子和神经通路。

在动物中，可以通过分析基因突变后的行为表型，筛选和找到调控行为的分子。在人类，通过全基因组分析，发现人群中与社会行为和认知相关的基因、以及基因与环境的相互作用。

We are interested in the molecular and cellular mechanisms of social behaviors.

Social behaviors are those initiated by one animal directed towards another animal of the same species, ranging from social interactions in animals to social relationships, politics and war in humans.

We use multidisciplinary approaches, integrating molecular biology, genetics, neurobiology, chemistry, modern imaging and electrophysiology, to study important and basic social behaviors.

Our models are Drosophila, mice and humans。

In flies and mice, we currently focus on aggression, courtship and maternal behaviors. We use quantifiable models and assays to analyze behaviors and their changes. Through molecular biology and genetics, we manipulate the activities of genes at specific time and locations, or the activity of neurons at specific time and locations, to determine the roles of molecules，neurons and brain regions, hoping to understand the molecules and circuitry required for specific behaviors.

In animals, we can also use genetic screens to discover molecules involved in behaviors. In humans, genomic analysis is used to find molecules and gene-environment interactions which are relevant to social cognition and behaviors.

代表性原始研究论文

Representative Publications

1. Liu W, Liang X, Gong J, Yang Z, Zhang YH, Zhang JX andRao Y.Social regulation of aggression by pheromonal activation of Or65a olfactory neurons in Drosophila.NatureNeuroscience, doi:10.1038/nn.2836, 2011 Jun. 19

2. Liu Y, Jiang Y, Si Y, Kim J-Y, Chen Z-F, andRao Y(2011). Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brain of male mice.Nature472:95-99

3. Zhou C, Rao Yong, andRao Y(2008). A subset of octopaminergic neurons are important for Drosophila aggression.Nature Neurosci11:1059-1061.

4. Li X, Gao X, Liu G, Xiong W, Wu J,Rao Y(2008). Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling.Nature Neurosci11:28-35

5. Guo W, Jiang H, Gray V, Dedhar S, andRao Y(2007). Role of the integrin-linked kinase (ILK) in determining neuronal polarity.Dev Biol306:457-468.

6. Jiang H., Guo W., Liang X.H., andRao Y..Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3b and its upstream regulators.Cell. 2005; 120: 123-135.

7. Liu G., Beggs H., Jürgensen C., Park H.T., Tang H., Gorski J., Jones K.R., Reichardt L.F., Wu J.Y., andRao Y..Netrin requires the focal adhesion kinase and the Src family kinases to induce axon outgrowth and to attract axons.Nature Neurosci. 2004; 7: 1222.

8. Ward M.E., Wu J.Y. andRao Y..Visualization of spatially and temporally regulated N-WASP activity during cytoskeletal reorganization in living cells.Proc Natl Acad Sci USA. 2004; 101:970-974.

9. Zhu Y., Yu T., Zhang X-C, Nagasawa T., Wu J.Y., andRao Y..Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons.Nat Neurosci. 2002; 5: 719-720.

10. Wong K., Ren X-R, Huang Y-Z, Xie Y., Liu G., Saito H., Tang H., Wen L., Brady-Kalnay S.M., Mei L., Wu J.Y., Xiong W-C, andRao Y..Signal Transduction in Neuronal Migration: Roles of GTPase Activating Proteins and the Small GTPase Cdc42 in the Slit-Robo Pathway.Cell. 2001; 107: 209-221.

11. Wu J.Y., Feng L., Park H-T, Havlioglu N., Wen L., Tang H., Bacon K.B., Jiang Z., Zhang X-C, andRao Y..Slit, a molecule known to guide axon projection and neuronal migration, inhibits leukocyte chemotaxis induced by chemotactic factors.Nature. 2001; 410: 948-952.

12. Wu W., Wong K., Chen J.H., Jiang Z.H., Dupuis S., Wu J.Y., andRao Y..Directional guidance of neuronal migration in the olfactory system by the protein Slit.Nature.1999; 400: 331-336.

13. Li H.S., Chen J.H., Wu W., Fagaly T., Yuan W.L., Zhou L., Dupuis S., Jiang Z., Nash W., Gick C., Ornitz D., Wu J.Y., andRao Y..Vertebrate Slit, a secreted ligand for the transmembrane protein Roundabout, is a repellent for olfactory bulb axons.Cell. 1999; 96: 807-818.

14. Li H.S., Tierney C., Wen L., Wu J.Y. andRao Y..A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal mesoderm.Development.1997; 124: 603-615.

15.Rao Y., Jan L.Y., and Jan Y.N.. Similarity of the product of the Drosophila neurogenic gene big brain to transmembrane channel proteins.Nature. 1990; 345: 163-167.

Minireview

Jiang H, and Rao Y. (2005). Axon formation: fate versus growth. Nat Neurosci 8:544-6.

综述

Reviews

饶毅,樊华轩,朱炳法,沈鼎鸿(1983).组胺受体与免疫的关系.上海免疫学杂志3:248-251.

樊华轩,饶毅,孙周(1983).心血管系统中组胺的作用及组胺受体.国外医学(生理病理

科学分册). 3:70-73.

Wu JY and Rao Y (1999). Fringe: defining borders by regulating the Notch pathway.Curr Opin Neurobiol9:537-543.

饶毅，吴瑛(2000).神经细胞迁移导向的分子机制.生理科学进展31:198-204.

Rao Y and Wu JY (2001). A neuronal migratory pathway and the evolution of a bigger brain.Nature Neurosci.4:860-862.

Wong K, Wu JY, and Rao Y (2002). Neuronal migration.Encyclopedia of Life Sciences, Nature Publishing Group.

Park HT, Wu JY and Rao Y (2002). Molecular control of neuronal migration.BioEssays24:821-827.

Wong K, Park HT, Wu JY and Rao Y (2002). Slit proteins: guidance cues for cells ranging from neurons and leukocytes.Curr Opin Genet Dev12:583-591.

Rao Y, Wong K, Ward M, Jurgensen C, and Wu JY (2002). Neuronal migration and molecular conservation with leukocyte chemotaxis.Genes Dev16:2973-2984.

Guan KL and Rao Y (2003). Signal transduction mechanisms mediating neuronal responses to guidance cues.Nature Rev Neurosci4:941-956.

Ward ME and Rao Y (2004). Investigations of neuronal migration in the central nervous system.In Guan, J.-L. (ed) Cell Migration: Developmental Methods and Protocols. Humana Press, Totowa, NJ.

Liu G and Rao Y (2004). Neuronal migration in the central nervous system.The Cognitive Neurosciences, 3rd edition, Gazzaniga MS, editor in chief, MIT press.

Jiang H, and Rao Y (2005).Axon formation: fate versus growth.Nature Neurosci8:544 – 546.

科学文化和科学史文章(部分)

饶毅(1996).纪念神经生物学家冯德培.《二十一世纪》1996年4月号，102－107页.

饶毅(1996).《中国生理学杂志》－一个优秀的研究期刊.《二十一世纪》1996年12月号，103页.

饶毅(1999).邹冈：在艰难中作出杰出研究的科学家.《华夏文摘》1999年3月19日.

饶毅(1999).神经科学.《二十一世纪》1999年4月号，101－108页.

饶毅(2001).几被遗忘的中国生命科学之父:林可胜.《世纪中国》2001年第一期.

饶毅(2002)中国科学的发展和挑战──以生命科学论文在国际期刊上的发表为例.

《二十一世纪》2002年2月号，83-93页.

饶毅、鲁白、邹承鲁(2004).中国科技需要的根本转变：从传统人治到竞争优胜体制.《自然》“中国之声II”增刊Nature 432 (Suppl), A12-A17, November 18, 2004