Qi Li,Ph.D.

Director of Genetic Screening Center, TIMBR/NIBS, Beijing, China

09/2004-07/2008    B.S., School of Life Science, Shandong Teachers’University

09/2008-07/2016    Ph.D., School of Life Science, Peking University

08/2016-10/2017    Postdoc, School of Life Science, Peking University

11/2017-present    Postdoc, National Institute of Biological Science

Adeno-associated virus (AAV) is currently one of the most widely used gene delivery tools in both scientific research and gene therapy. AAV has many advantages, including low immunogenicity, low genomic integration, high transduction rate, and stable and persistent expression. The Genetic Screening Center provides AAV technical services including vector construction, packaging, purification, titration and functional test for different labs. The Genetic Screening Center provides multiple common serotypes of recombinant Adeno-associated virus and helps construct AAVs for either expression or knockout of target genes. Moreover, the center is committed to develop and evolve new serotype vectors according to different labs’ demand and interest.

1. Cao, Y., J. Zheng, H. Wan, Y. Sun, S. Fu, S. Liu, B. He, G. Cai, Y. Cao, H. Huang,Q. Li, Y. Ma, S. Chen, F. Wang and H. Jiang (2023). "A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease."EMBO J42(13): e113033.

2. He, B., H. Yu, S. Liu, H. Wan, S. Fu, S. Liu, J. Yang, Z. Zhang, H. Huang,Q. Li, F. Wang, Z. Jiang, Q. Liu and H. Jiang (2022). "Mitochondrial cristae architecture protects against mtDNA release and inflammation."Cell Rep41(10): 111774.

3. Wang, G.*,Q. Li*, J. Xu, S. Zhao, R. Zhou, Z. Chen, W. Jiang, X. Gao, S. Zhou, Z. Chen, Q. Sun, C. Ma, L. Chen, B. Shi, Y. Guo, H. Wang, X. Wang, H. Li, T. Cai, Y. Wang, Z. Chen, F. Wang and Q. Liu (2022). "Somatic genetics analysis of sleep in adult mice."J Neurosci42(28): 5617-5640.

4. Zhou, R.*, G. Wang*,Q. Li, F. Meng, C. Liu, R. Gan, D. Ju, M. Liao, J. Xu, D. Sang, X. Gao, S. Zhou, K. Wu, Q. Sun, Y. Guo, C. Wu, Z. Chen, L. Chen, B. Shi, H. Wang, X. Wang, H. Li, T. Cai, B. Li, F. Wang, H. Funato, M. Yanagisawa, E. E. Zhang and Q. Liu (2022). "A signalling pathway for transcriptional regulation of sleep amount in mice."Nature612(7940): 519-527.

5. Deng, B.*,Q. Li*, X. Liu*, Y. Cao*, B. Li, Y. Qian, R. Xu, R. Mao, E. Zhou, W. Zhang, J. Huang and Y. Rao (2019). "Chemoconnectomics: Mapping Chemical Transmission in Drosophila."Neuron101(5): 876-893 e874.

6. Petruccelli, E.,Q. Li, Y. Rao and T. Kitamoto (2016). "The Unique Dopamine/Ecdysteroid Receptor Modulates Ethanol-Induced Sedation in Drosophila."J Neurosci36(16): 4647-4657.

7. Song, S., Y. Yuan, J. Lu,Q. Li, Z. Zhu, Q. Fan, Y. Xue, Z. C. Lai and W. Zhang (2013). "The Drosophila ortholog of breast cancer metastasis suppressor gene, dBrms1, is critical for developmental timing through regulating ecdysone signaling."Dev Biol380(2): 344-350.