Hui Jiang, Ph.D.

Associate Professor, TIMBR, Associate Investigator, NIBS, Beijing, China

Education

2008    Ph.D. Institute of Neuroscience, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences

2001    BS. Biochemistry, Nanjing University, China

Experience

2022-    Associate Professor, TIMBR, Associate Investigator, NIBS, Beijing, China

2016-2022    Assistant Investigator, National Institute of Biological Sciences, Beijing, China

2011-2016    TIMBR/NIBS Fellow, National Institute of Biological Sciences, Beijing, China

2008-2011    Postdoctoral research with Dr. Xiaodong Wang, UT-Southwestern, USA

Research

Mitochondrion is the powerhouse of the cell and a key player in apoptosis and inflammation. Mitochondrial dysfunction is a driving force of aging and aging-related degenerative diseases. We exploit yeast, cultured cell, and mouse models to uncover mechanisms surveying mitochondrial quality and maintaining mitochondrial homeostasis. We focus on the following questions: 1. mitochondrial quality control mechanisms, including protein quality control and mitophagy; 2. the pathological mechanisms and therapeutic targets for mitochondrial diseases; 3. the relationship between mitochondrial damage, chronic inflammation, and degenerative diseases.

Publications

1. Cao Y, Zheng J, Wan H, Sun Y, Fu S, Liu S, He B, Cai G, Cao Y, Huang H, Li Q, Ma Y, Chen S, Wang F,Jiang H. A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease.EMBO J. 2023 Mar 10:e113033. doi: 10.15252/embj.2022113033.

2. Yang J, Chen P, Cao Y, Liu S, Wang W, Li L, Li J, Jiang Z, Ma Y, Chen S, Zheng S, Qi X*,Jiang H*. Chemical inhibition of mitochondrial fission via targeting the DRP1-receptor interaction.Cell Chem Biol. 2023 Feb 17:S2451-9456(23)00033-8. doi: 10.1016/j.chembiol.2023.02.002.

3. He B, Yu H, Liu S, Wan H, Fu S, Liu S, Yang J, Zhang Z, Huang H, Li Q, Wang F, Jiang Z, Liu Q,Jiang H.Mitochondrial cristae architecture protects against mtDNA release and inflammation.Cell Reports.2022 Dec 6; 41(10):111774. doi: 10.1016/j.celrep.2022.111774.

(Recommended byChandel N: Faculty Opinions Recommendation of [He B et al., Cell Rep 2023 41(10:111774)]. InFaculty Opinions, 13 Feb 2023; 10.3410/f.742441445.793597661)

4. Zheng J, Cao Y, Yang J,Jiang H. UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy.EMBO Reports. 2022 Aug 18:e54859. doi: 10.15252/embr.202254859.

5. Liu S, Ma Y,Jiang H. Protocols for analyzing metabolic derangements caused by increased NADH/NAD⁺ratio in cell lines and in mice.STAR Protocols.2022 Mar 18;doi:10.1016/j.xpro.2021.101120.

6.Liu S, Fu S, Wang G, Cao Y, Li L, Li X, Yang J, Li N, Shan Y, Cao Y, Ma Y, Dong MQ, Liu Q,Jiang H. Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD⁺to alleviate mitochondrial diseases.Cell Metabolism.2021 Oct 5;33(10):1974-1987.

(Previewed byThe Gro3p factor: Restoring NAD⁺/NADH homeostasis to ameliorate mitochondrial disease.CellMetabolism. 2021Oct 5;33 (10):1905-1907.)

7. Liu S, Liu S, He B, Li L, Li L, Wang J, Cai T, Chen S,Jiang H. OXPHOS deficiency activates global adaptation pathways to maintain mitochondrial membrane potential.EMBO Reports. 2021 Apr 7; 22(4): e51606.

8. Li L^#, Zheng J^#, Wu X*,Jiang H*. Mitochondrial AAA-ATPase Msp1 detects mislocalized tail-anchored proteins through a dual-recognition mechanism.EMBO Reports. 2019 Apr; 20(4): e46989.

9. Wu X*, Li LL,Jiang H*. (2018). Mitochondrial inner-membrane protease Yme1 degrades outer-membrane proteins Tom22 and Om45.J Cell Biol. 2018 Jan 2; 217(1):139-149.

10. Wu X*, Li LL,Jiang H*. (2016). Doa1 targets ubiquitinated substrates for mitochondria-associated degradation.J Cell Biol. 2016 Apr 11; 213(1):49-63.

(Commented byDoa1 is a MAD adaptor for Cdc48.J Cell Biol. 2016 Apr 11;213 (1):7-9.)

11. Jiang X, Li L, Ying Z, Pan C, Huang S, Li L, Dai M, Yan B, Li M,Jiang H, Chen S, Zhang Z, Wang X(2016). A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway.Mol Cell. 2016 Jul 21;63(2):229-39.

12.Jiang X,Jiang H, Shen Z, Wang X. (2014).Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis.Proc Natl Acad Sci U S A.2014 Oct 14;111(41):14782-7.

13. Wang Z,Jiang H, Chen S, Du F, Wang X. (2012).The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways.Cell. 2012 Jan 20;148(1-2):228-43.

14. Guo W,Jiang H, Gray V, Dedhar S, Rao Y (2007).Role of the integrin-linked kinase (ILK) in determining neuronal polarity.Dev Biol. 306:457-68.

15. Ward ME,Jiang H, Rao Y (2005). Regulated formation and selection of neuronal processes underlie directional guidance of neuronal migration.Mol Cell Neurosci30:378-87.

16.Jiang H, Guo W, Liang X, Rao Y (2005). Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3beta and its upstream regulators.Cell120:123-35.

(Highlighted by Science,Nature Review Neuroscience,andCurrent Biology)

#co-first author, * co-correspondingauthor.

17. Liu S, Liu S,Jiang H. Multifaceted roles of mitochondrial stress responses under ETC dysfunction - repair, destruction and pathogenesis.FEBS J. 2022 Nov;289(22):6994-7013. doi: 10.1111/febs.16323.

18.Jiang H.Quality control pathways of tail-anchored proteins.BBAMol Cell Res.2021 Feb;1868(2):118922.

19. Zheng J, Li L,Jiang H.Molecular pathways of mitochondrial outer membrane protein degradation.Biochem Soc Trans.2019 Oct 31; 47(5):1437-1447.

20.Jiang H, Rao Y (2005). Axon formation: fate versus growth.Nat Neurosci.8:544-6.